Vaccine against human Papilloma Virus

At present two prophylactic human papilloma virus (HPV) vaccines are commercially available. The tetravalent vaccine comprised of four VPH types (6, 11, 16, and 18) distributed in the national program in Colombia and the bivalent vaccine comprised of VPH types 16 and 18, respectively. Types 16 and 18 are accountable for 70% of cervical cancer, most vulva, vagina, penis, anus and one third of oropharyngeal cancer. Types 6 and 11 are responsible for 90% of genital warts or condylomas and of recurrent laryngeal papillomatosis. Controlled clinical trials carried out in 30 countries with over 40,000 adolescents and young women have clearly showed that both vaccines are safe and prevent cervix cancer in situ with almost a 100% efficacy1 and a decrease of genital warts and of high degree cervical intraepithelial neoplasia (CIN) lesions have been reported in national immunization programs.